In this video YouTube user Quetzalqoatl99 shows him playing Skyward Sword with an Xbox 360 Controller. To play like this he is using Dolphin, a program that lets you emulate Wii and GameCube games on your PC giving HD quality.
The uploader was nice enough to provide a profile that you can load into Dolphin so you don't have to go through the process of mapping all of the buttons. Unfortunately, he wasn't nice enough to leave embedding enabled...but that's easy enough to get around. We all look forward to the Nintendo Wii U when Zelda games will look even better.